Targeted Oncology

Choosing Wisely in CLL: A Deep Dive Into Frontline Treatment

Explore 2026 CLL frontline choices, from all-oral acalabrutinib–venetoclax to MRD-guided care, plus pipeline advances and ...

AI algorithm identifies cells across diverse biological images, cutting hours of manual labeling

Imaging is a critical technique in biology—from identifying cancerous cells in biopsies to observing how immune cells like ...
ascopubs.org

Chemoimmunotherapy With a Modified Hyper-CVAD and Rituximab Regimen Improves Outcome in De Novo Philadelphia Chromosome–Negative Precursor B-Lineage Acute Lymphoblastic Leukemia

Therapy-Related Myeloid Neoplasms in Patients With Acute Promyelocytic Leukemia Treated With All-Trans-Retinoic Acid and Anthracycline-Based Chemotherapy The prognostic relevance of immunophenotypic ...
IEEE

Learning-Assisted Search Path Reconstruction Empowers Evolution Algorithm for Optimization

Abstract: Evolutionary algorithms serve as a pivotal tool in addressing closed box problems, finding widespread applications across diverse academic disciplines and engineering domains. Despite their ...
IEEE

NuSC: An Effective Local Search Algorithm for Solving the Set Covering Problem

Abstract: The set covering problem (SCP) is a fundamental NP-hard problem in computer science and has a broad range of important real-world applications. In practice, SCP instances transformed from ...
PNAS

PD-1 expression identifies proliferating malignant CLL B cells and is a potential biomarker of response to BTK inhibitor therapy

Contributed by Rafi Ahmed; received December 23, 2024; accepted August 2, 2025; reviewed by Carl H. June and Alan J. Korman Patients with CLL often have an abnormal T compartment, with an inverted CD4 ...
ascopubs.org

Table of Contents

Leveraging Digital Technology and Artificial Intelligence to Describe the Real-World Belgian Chronic Lymphocytic Leukemia Patient Population: The BE-CLLEAR Study Matthias Vanderkerken et al. full text ...
jmg.bmj

Targeted next-generation sequencing detects rare genetic events in pheochromocytoma and paraganglioma

Background Knowing the genetic status of patients affected by paragangliomas and pheochromocytomas (PPGL) is important for the guidance of their management and their relatives. Our objective was to ...
BMJ

Real-world evidence studies into treatment adherence, thresholds for intervention and disparities in treatment in people with type 2 diabetes in the UK

Purpose The University of Surrey-Lilly Real World Evidence (RWE) diabetes cohort has been established to provide insights into the management of type 2 diabetes mellitus (T2DM). There are 3 areas of ...
BMJ

Effect of different visual presentations on the public’s comprehension of prognostic information using acute and chronic condition scenarios: two online randomised controlled ...

Objectives To assess the effectiveness of bar graph, pictograph and line graph compared with text-only, and to each other, for communicating prognosis to the public. Design Two online four-arm ...
gut.bmj

Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease

Dr Z M Younossi, The Cleveland Clinic Foundation, Department of Gastroenterology, Desk S-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. BACKGROUND AND AIMS To develop and assess a disease specific ...