Several methods have been described recently that permit researchers to exert post-translational control over gene products. An intein-based method shows it is a strong contender in the field by ...

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilising cell structure to catalysing chemical reactions, ...

The SCN1A gene is too large to fit into aconventional viral delivery systems. Scientists overcame this hurdle with a pioneering "split-intein" mechanism, which is like two separate trucks, delivering ...

Self-removing tags can be used for simple and effective purification of recombinant proteins and peptides. The key component of these tags is an intein, which is a protein element with the ability to ...

Long-standing problem solved: Researchers discover that misfolding prevents efficient utilisation of so-called split inteins as ‘protein glue’ Proteins are the building blocks of life. They consist of ...

Why do problems occur with a special variant of ‘protein glues’, the split inteins, that severely limit their use in producing proteins? A team from the University of Münster has now answered this ...