A new study shows cancer cells depend on vitamin B7 to use pyruvate as backup fuel, opening new strategies for targeted therapy.

The tricarboxylic acid (TCA) cycle is a pivotal source for mitochondrial NADH and the core metabolic route for production of many biosynthetic precursors. Over the past 15 years, oncogenic mutations ...

Researchers at Duke University Medical Center and Wake Forest University School of Medicine have identified ALDH4A1, a mitochondrial proline-metabolizing enzyme, as a third structural component of the ...

Having considered localization of respiratory functions in mitochondria and in prokaryotic cells, it’s time to return to the eukaryotic context and follow a molecule of pyruvate across the inner ...

HOW Does 6-PPDQ disrupts the citric acid cycle in caenorhabditis elegans. FAYETTEVILLE, GA, UNITED STATES, July 2, 2025 /EINPresswire / -- Researchers explore how 6-PPD quinone (6-PPDQ), an ...