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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
By combining gene engineering, Ca²⁺ imaging, and detailed functional tests, the team shows with high precision that skeletal muscle contraction is mainly DICR-driven. This long-accepted mechanism is ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
3 Department of Biomedical Engineering, Orthopaedic Research Center, Cleveland Clinic Foundation, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA 4 Graduate Program in ...
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