Obesity has become a global epidemic affecting diverse populations and leading to metabolic syndrome across different sexes and age groups. A significant aspect of obesity is the development of leptin ...

Thirty years after its discovery, scientists are eyeing leptin with renewed interest, for everything from weight loss drug ...

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use. Featured in the February ...

Forbes contributors publish independent expert analyses and insights. Questions about hunger and fullness come up constantly in my clinic. Many patients try to manage appetite through willpower alone, ...

Scientists have discovered a brain signaling pathway that eliminates body fat without reducing food intake by targeting ...

Objective Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design ...

A paper published in the May issue of Diabetes implicates triglycerides in the mechanism of leptin resistance. These fats, elevated in obesity, are what disrupt the transport of the hormone across the ...

Your defended weight range can gradually shift upward through hormonal, metabolic, environmental, and microbiome-driven changes that push the body toward higher weight. Questions about why weight gain ...