If you like thinking of amyloid precursor processing in Boolean logic terms, that is α- or β-secretase cleavage, then you may want to expand your logic board to include an “and.” Using mass ...

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed ...

Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein ...

A new study strengthens the idea that reelin, an extracellular matrix protein essential for brain development, works, at least in part, by binding amyloid precursor protein (APP). In the June 10 ...

It's been 30 or so years since amyloid beta precursor protein (APP) was first pinpointed as the precursor of the amyloid beta (AB) peptide that is the main constituent of plaques found in the brains ...

Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive memory loss and a significant decline in mental functions. Past studies have shown that people with AD exhibit a buildup ...

Amyloid fibrils are infamous for the role they play in serious neurological diseases in humans, such as Parkinson's or Alzheimer's. One trigger for Alzheimer's disease is the misfolding and ...

(A, B) ALP staining and activity detection were performed after treating cells with APPswe or BMP2 for 5 days or 7 days. (C, D) ARS staining and semiquantitative analysis were used to detect calcium ...

A new study published in the journal JAMA Neurology in April 2020 seems to indicate that higher brain amyloid levels represent early Alzheimer's disease (AD). Amyloid-beta is a significant biomarker ...

Researchers have developed a potential new peptide-based drug delivery system by repurposing fibrils that contribute to Alzheimer’s disease pathogenesis. Researchers at the University of North ...